Arbutin, Alpha Arbutin, Beta Arbutin

$101.30/KG
Specification:
Test by: HPLC
Quantity:
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Arbutin Introduction

Arbutin is commercially used as a skin-whitening agent in cosmetic industry. It works by competitive inhibition of tyrosinase, a key enzyme in the synthesis of melanin.

Depending on the spatial structure of the glycosidic linkage between glucose and hydroquinone, Arbutin forms two epimers: α-Arbutin and β-Arbutin.

Product name

CAS Number

Molecular formula

Molecular structure

Alpha Arbutin

84380-01-8

C12H16O7

                     

Beta Arbutin

497-76-7

C12H16O7

 

                   

Botanical Source Of Beta-Arbutin: bearberry

Beta Arbutin

Beta Arbutin is commonly referred to as just Arbutin. It is can be naturally extracted from plants such as bearberry and synthesized by chemical method. Beta Arbutin is currently one of the most widely used hypopigmenting agents in cosmetics, while plant-derived drugs containing Beta-Arbutin were initially used for the treatment of urinary tract infections, cystitis, kidney stones, and as diuretics in the medical field.

Alpha Arbutin

Alpha Arbutin is enzymatically synthesized from hydroquinone and saccharides through transglycosylation reaction. Various carbohydrate-active enzymes such as α-amylase, α-glucosidase, transglucosidase, sucrose phosphorylase, and dextransucrase have been employed to synthesize Alpha Arbutin. It is one of the most advanced skin lightening ingredients on the market.

Arbutin Specification(COA)

ANALYSIS

SPECIFICATION

RESULTS

Assay

≥99.0%

99.20%  HPLC

Appearance

White crystalline powder

Complies

Melting Point

199~201±0.5℃

200.5℃

PH(1% water solution)

5.0-7.0

5.92

Specific Optical Rotation

-66±2°

-66.24°

Loss on drying

≤0.5

0.16%

Residue on ignition

≤0.5

1.06ppm

Hydroquinone

≤10ppm

Complies

Heavy metals

≤20ppm

Complies

As

≤2ppm

Complies

Total Plate Count

≤300cfu/g

Complies

Total Yeast Count

≤100cfu/g

Complies

 

ANALYSIS

SPECIFICATION

RESULTS

Assay

≥99.5%

99.90%   HPLC

Hydroquinone

Negative

Negative

Appearance

White powder

Complies

Melting Point

202~210℃

205.6-208.0 ℃

Specific Optical Rotation

[a]20D= + 174.0°~+186.0°

+178.81°

Infrared peak value

1514cm-1; 1229 cm-1; 1215 cm-1; 1059 cm-1; 1034 cm-1

1514cm-1; 1229 cm-1; 1215 cm-1; 1059 cm-1; 1034 cm-1

Solubility

Soluble in water, slightly soluble in ethanol

Complies

Clarity

Solution should be clarify, none suspended matters

Complies

PH(1% water solution)

5.0-7.0

6.20

Loss on drying

≤0.5%

Complies

Residue on Ignition

≤0.5%

Complies

Heavy Metal

Total heavy metals

≤10ppm

Complies

Lead

≤2ppm

Complies

Arsenic

≤2ppm

Complies

Microbiological Tests

Total Plate Count

≤100cfu/g

Complies

Total Yeast & Mold

≤50cfu/g

Complies

E. Coli.

Negative

Negative

Salmonella

Negative

Negative

Staphylococcus

Negative

Negative

 

Arbutin Flow Chart

Alpha Arbutin Flow Chart

Beta Arbutin Flow Chart

HPLC Chromatogram Of Arbutin

  HPLC Chromatogram Of Alpha Arbutin   HPLC Chromatogram Of Beta Arbutin

Arbutin Solubility

  Dissolved in water Dissolved in oil Dissolved in propylene glycol
Alpha Arbutin
 
Beta Arbutin

Arbutin Benefit and Addition level

Skin whitening

Arbutin is a tyrosinase inhibitor. It inhibit the formation of melanin by blocking the synthesis of dopamine and dopaquinone. 

Recommended addition level —— 1-3% (Beta-Arbutin); 0.2-2% (Alpha-Arbutin)

Arbutin application

Arbutin is used as a skin whitening agent in cosmetic formulations. Arbutin soap, cream, serum and lotion are among the major lightening products in the market.

Arbutin’s advantage over traditional skin-whitening products:

Arbutin can inhibit melanogenesis without causing melanocyte toxicity, unlike traditional depigmenting agents such as hydroquinone, corticosteroids.


Arbutin cosmetics examples

Arbutin Cosmetic Formula Reference

Whitening cream

Anti-freckle whitening essence

note

  1. β-Arbutin breaks down easily in acidic conditions, so the pH value of cosmetics containing β-Arbutin should be about 7.0
  2. Please dissolve β-Arbutin in 50℃ hot water before adding it to skin whitening products. (β-Arbutin is soluble in hot water, methanol or alcohol. β-Arbutin is partially soluble in cold water. β-Arbutin is insoluble in aether, chloroform or benzene.)
  3. Antioxidants should be added to cosmetics containing β-Arbutin.

Package and Storage

Package: Aluminium foil bag with plastic bag for 1-10kg. Paper drum with two plastic bags for 25kg.

Storage: Please tightly sealed Arbutin in containers. Store it in a cool dry place and away from sunlight and oxidizing agents.

Remarks

A customer from Nigeria: 

Your Arbutin is good. Thanks to you and your team. I will also buy the Tetrahydocucurmin, and small of glabridin.

A customer from Rwanda: 

Very good. I will keep you posted and I have noticed brightening effect with the very first use!!!

Why there is low priced Alpha Arbutin on the market?

learn more

Melanins are irregular polymeric structures derived from the amino acid tyrosine, and tyrosinase is known to be one of the key enzymes in mammalian melanin synthesis.

Tyrosinase is a copper-containing enzyme that catalyzes the rate-limiting step of melanin synthesis, which is oxidation of the aromatic amino acid tyrosine to DOPA and subsequently to DOPA-quinone. DOPA-quinone is then converted by multi-step reactions to melanin. As a result, tyrosinase is responsible for the formation of pigments such as melanins and other polyphenolic compounds from tyrosine by oxidation reactions.

  • Miracle Skin Whiting Effective "Alpha-Arbutin" Extracted From Natural Bearberry
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    Arbutin Manufacturers And Laboratory Shows

    Arbutin, Alpha Arbutin, Beta Arbutin factory

    With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.

    Arbutin, Alpha Arbutin, Beta Arbutin manufacturer GMP Production Line

    Plant extract testing laboratory

    Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.

    Our Mission And Philosophy

    Where to buy Arbutin, Alpha Arbutin, Beta Arbutin? Where to find good Arbutin, Alpha Arbutin, Beta Arbutin Manufacturers and Arbutin, Alpha Arbutin, Beta Arbutin suppliers? Where can i Looking for Arbutin, Alpha Arbutin, Beta Arbutin purchase? Where can i purchase Arbutin, Alpha Arbutin, Beta Arbutin price and where to get Arbutin, Alpha Arbutin, Beta Arbutin for sale? Is that the very question that lingers in your mind every time you do purchasing? Well, that should not be your headache any longer since we are committed to help you get rid of it completely. We can provide you with the safest and most effective Arbutin, Alpha Arbutin, Beta Arbutin. To ensure the quality of any products that you buy on your platform, we have signed an investment and cooperation agreement with Natural Medicine Public Technical Service Platform, the largest and most professional third-party testing agency in China. Any extract you buy will have to pass the test of our strategic partner before delivery.
    To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.