Niacinamide

$22.00/KG
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Niacinamide Introduction

Niacinamide belongs to a form of vitamin B, also named nicotine amine, vitamin B3. It is an important derivative of niacin, widely existing in various organisms. Niacinamide can react with phosphoric acid, ribose and adenine to form coenzyme Ⅰ and coenzyme Ⅱ. And then it promotes proteins, fats, DNA synthesis and cell's energy metabolism. Therefore, it can effectively inhibit the melanin precipitation, weaken the color spots, and has a good whitening effect. At present, it is mainly used in whitening skin-care products and hair-care products.

Product Name

Molecular Formula

CAS Number

Molecular Weight

INCI Name

Molecular Structure

Niacinamide

C6H6N2 O

98-92-0

112.1g/mol

Niacinamide

Where are Niacinamide extracted from?

Niacinamide is mainly produced by synthesis, which can be divided into chemical synthesis and biological synthesis.

Plamed adopts the biological method to produce Niacinamide, because the method is pollution-free and suitable for large-scale production to meet customers' needs.

 

Methods

Advantages

Disadvantages

Chemical

Use 3-methylpyridine directly to produce Niacinamide.

Only one step to produce Niacinamide. The process is simple and the catalyst is easy to obtain.

Serious environmental pollution, high consumption of raw materials, unstable production quality, difficult for large-scale production.

Biological

First produce 3-cyanopyridine using microbial catalyst, then hydrolyze 3-cyanopyridine to obtain Niacinamide.

No pollution, high technical, low consumption of raw materials, stable product quality, suitable for large-scale industrial production.

The process is relatively complex, but the science and technology progress can overcome the shortcoming.

Niacinamide Specification(COA)

Items

Specifications

Result

Assay

≥99.0%

99.4%

Appearance

White crystalline powder

White crystalline powder

Physical Characteristic

Melting point

128.0℃-131.0℃

130.0℃-131.0℃

Loss on Drying

≤0.5%

0.30%

Residue on ignition

≤0.1%

0.05%

Related substances

≤0.5

≤0.4

Readily carbonized substance

Conforms

Conforms

Clarity and color of solution

Clear and colorless

Clear and colorless

Absorption coefficient

E1 cm 1%: 417-443

437

pH

5.5-7.5 (10% solution)

5.8

Heavy Metal

Total Heavy Metals

≤20ppm

Conforms

Extraction Process

 

Niacinamide Benefit

1. Prevent melanin from precipitating into horny cells.

When melanin is transferred to horny cells, it will make skin darker. Niacinamide acts on the already produced melanin, and effectively inhibits the transmission of about 35% to 40% of melanin from melanin cells to keratinocytes. Thus it can reduce excessive melanin deposition. Clinical trials have shown that using niacinamide moisturizer can significantly diminish the area and number of brown spots on the skin.

2. Promote the melanin cells metabolism.

Nicotinamide can be absorbed by cells directly because of its small molecule. It can penetrate into the waterproof layer of skin's corneum within two hours, and act on the inner layer of skin. Applying nicotinamide to the skin can promote the formation of energy molecules in the body. And it passes through the cuticle layer to the dermal connective tissue and fiber. Then it directly reaches the bottom of the cell to promote cell metabolism.

3. Improve skin synthetic epidermal protein

Nicotinamide can synthesize protein on skin's surface. Thus it can improve skin texture and replenish moisture. In 1990, the European patent EP0-396-422 found that adding nicotinamide, sun-screening agents containing UVA, UVB and 0.1% ~ 5% silicone compound into cream formula, that can promote skin whitening and sun protection function.

Niacinamide application and dosage

Niacinamide is mainly used in cosmetics products of whitening, moisturizing, wrinkle and acne removal, and shampoo. It is usually  mixed with fruit acid, salicylic acid, retinol, glycerol to prepare cosmetics. Adding it into shampoo can  relieve itching and prevent hair loss.

Specification

Reference Dosage

Niacinamide 99%

0.5%-2%

Attention

When the concentration of Niacinamide exceeds 5%, it is hard to be absorbed by the skin. Less than 5% amount will be effective for skin care. Therefore, the product should be added appropriately within the dosage range.

PH value of Niacinamide should be limited to 5~7. When pH value is below 5, it will be decomposed to niacin. Niacin can cause skin irritation.

Application cases of Nicotinamide in cosmetics at home and abroad:

Country

Brand

Product

USA

TruSkin Naturals

Vitamin C-Plus Super Serum, Anti Aging Anti-Wrinkle Facial Serum

The Ordinary

Niacinamide 10% + Zinc 1%

InstaNatural

Niacinamide 5% Face Serum

CeraVe

Skin Renewing Night Cream, Sunscreen Face Lotion, Foaming Facial Cleanser

Face n Earth, LLC

Oil-Free Cream

Olay

Regenerist Regenerating Serum

Body Merry

Breakthrough Night Cream

Dermedicine

Natural Niacinamide Ultimate Strength Vitamin B Cream for Face

LuxaDerme

Brightening Bio Cellulose Face Sheet Mask 

Korea

The Face Shop

Anti Aging Serum

Japan

SK-Ⅱ

Aura Essence

France

Cetaphil

Body Moisturizer

Bioderma

Atoderm PP Balm

Reference Formula

Skin care lotion

Ingredient

Content%

Ingredient

Content%

Niacinamide

1.0

Glyceryl monostearate

2.0

Stearic acid

2.0

Spermol

3.0

Cholesterol

0.5

Vaseline

2.0

Squalane

10.0

Liquid paraffin

10.0

Polydimethylsiloxane

1.0

Methylparaben

0.1

Butylparaben

0.1

N-stearyl glutamic acid sodium

1.0

Glycerin

5.0

Propanediol

3.0

Thallus laminariae PE

1.0

Water

Add to 100

Whitening cream

Ingredient

Content%

Ingredient

Content%

Niacinamide

3.20

Methylparaben

0.15

Stearic acid

16.00

Isopropyl palmitate

4.40

PARSOL1789(Sun-screening agent)

0.50

Fragrance

0.20

PARSOLMCX(Sun-screening agent)

1.20

Deionized water

Add to 100.00

Dimethyl polysiloxane

0.20

Shampoo

Ingredient

Content%

Ingredient

Content%

Niacinamide

0.1

D-panthenol

0.25

Naphtha

3.50

Hydroxypropyl methyl cellulose

0.60

Mixed-alcohol

4.80

Deionized water

Add to100.00

Monostearin

0.30

Sovermol(r)760

0.25

Polyglycerol/methyl glucose-distearate

0.40

Methylparaben

0.20

Cetyl-trimethyl ammonium chloride

3.00

Propylparaben

0.20

Glucose monohydrate

2.00

Dehyquart(r)F75

0.35

Safety

  • Cosmetic, Toiletry and Fragrance Association(CTFA) and European Union (EU) both have specified Niacinamide as a raw material of cosmetics.
  • On the Announcement of Name List of Cosmetics Raw Material published by China Food and Drug Administration(CFDA) in 2014, and The Catalog Of the International Cosmetics Raw Material Standard English Name issued by CAFFCI in 2010 both include Niacinamide. There is no reports showing its insecurity for external use.

Product packaging

0-1kg

1-10kg

10-25kg

Shipping

By Express By Air By Sea
Suitable for under 50kg
Fast: 7-15 days
High cost
Door to door service
easy to pick up the goods
Suitable for more than 50kg
Fast: 7-15 days
High cost
Port to port
professional broker needed
Suitable for more than 500kg
Slow: 7-45 days
Low cost
Port to port
professional broker needed

How To Buy

Paypal(Suitable for under 500USD) Western Union(Suitable for under 5000USD) Bank Transfer(Suitable for all amount)
15% charges
Arrive time: immediately
Easy to handle
Reasonable bank charges
Arrive time: immediately
Easy to handle
Reasonable bank charges
Arrive time:2-3 work days
Easy to handle

Manufacturers And Laboratory Shows

Niacinamide factory

With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.

Niacinamide manufacturer GMP Production Line

Plant extract testing laboratory

Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.

Our Mission And Philosophy

Where to buy Niacinamide? Where to find good Niacinamide Manufacturers and Niacinamide suppliers? Where can i Looking for Niacinamide purchase? Where can i purchase Niacinamide price and where to get Niacinamide for sale? Is that the very question that lingers in your mind every time you do purchasing? Well, that should not be your headache any longer since we are committed to help you get rid of it completely. We can provide you with the safest and most effective Niacinamide. To ensure the quality of any products that you buy on your platform, we have signed an investment and cooperation agreement with Natural Medicine Public Technical Service Platform, the largest and most professional third-party testing agency in China. Any extract you buy will have to pass the test of our strategic partner before delivery.
To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.