Test by: HPLC/UV
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Nattokinase Introduction

Nattokinase, a potent fibrinolytic enzyme, is one of many enzymes derived from a popular Japanese food called natto. It has been found to have blood clot dissolving abilities and prevents the aggregation of red blood cells. It is used to make anti-clotting medicine.

About the measurement (fu/g): The potency of nattokinase is often measured by the enzyme’s ability to degrade fibrin over a given amount of time, and is represented by Fibrinolytic Units.

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Source of Nattokinase: Natto

Natto is a traditional Japanese fermented soybean dish and dietary staple that has been used in Japanese culture for more than 1,000 years for its popular taste. Natto is simple to make, requiring only soybeans, straw and water. Steamed beans are mixed with straw, which contains the bacteria Bacillus subtilis, and left to ferment for 24 hours. The resulting product is sticky and has a stringy, web-like consistency. It has been used as a folk remedy for heart and vascular diseases. 

Nattokinase Specification(COA)

Extraction Process

Nattokinase Benefit and Dosage

1. Anti-clotting and Fibrinolysis

Nattokinase exhibits direct fibrinolytic properties that may degrade fibrin and reduce the risk of cardiovascular complications. This direct activity is lost upon destruction of the enzyme (heat treatment or digestion), but the peptides from nattokinase appear to increase levels of plasminogen activator which also has a fibrinolytic effect indirectly. The fibrinolytic activity of nattokinase is reportedly 4 times that of plasmin.

Recommended Dosage —— 1,300mg taken twice daily

2. High blood pressure

Research suggests that prolonged supplementation (about 8 weeks) of nattokinase daily can reduce systolic and diastolic blood pressure in people with mildly high blood pressure. Nattokinase appears to exert mixed-type inhibition on the Angiotensin Converting Enzyme, and this is thought to be related not to enzyme activity but due to bioactive peptides from nattokinase. The byproducts of enzyme digestion (when the enzyme nattokinase is destroyed) appear to be bioactive dipeptides and tripeptides, which have ACE inhibitory potential or may otherwise reduce blood pressure

Recommended Dosage —— an oral dose of 2,000 FU per capsule once daily

3. Deep vein thrombosis (DVT)

Nattokinase can be used for the prevention of deep vein thrombosis (DVT) during long airline flights (7-8 hours). Nattokinase, in combination with pycnogenol, was reported to decrease the chance of getting a blood clot in the legs determined by ultrasound of the venous system during long flights. Edema scores were also reduced, possibly due to the diuretic effect of pycnogenol.

Recommended Dosage —— taken two capsules 2 hours before the flight and then again 6 hours later

*The Content here is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician with any questions you may have regarding a medical condition.

How does Nattokinase work?

Nattokinase enhances the body's natural ability to fight blood clots in two ways: the direct and the indirect.

  • Prevents blood clots from forming
  • Dissolves existing blood clots
  • Dissolves fibrin
  • Enhances the body's production of plasmin and other clot-dissolving agents, including urokinase

Nattokinase application




Medical and health industry

Soft gel capsules; hard shell capsules; tablets

cardiovascular health

Food industry

Functional food

Cardiovascular health


  1. Nattokinase is very safe when used according to the recommended dosage. The traditional Japanese food Natto has been used safely for more than 1,000 years. The safety record of its potent fibrinolytic enzyme, Nattokinase, is based upon the long-term traditional use of the food and recent scientific studies.
  2. Generally, people with bleeding disorders, or taking anti-clotting medication, should use this product only under the close supervision of a medical doctor.

Product packaging





By Express By Air By Sea
Suitable for under 50kg
Fast: 7-15 days
High cost
Door to door service
easy to pick up the goods
Suitable for more than 50kg
Fast: 7-15 days
High cost
Port to port
professional broker needed
Suitable for more than 500kg
Slow: 7-45 days
Low cost
Port to port
professional broker needed

How To Buy Nattokinase

Paypal(Suitable for under 500USD) Western Union(Suitable for under 5000USD) Bank Transfer(Suitable for all amount)
15% charges
Arrive time: immediately
Easy to handle
Reasonable bank charges
Arrive time: immediately
Easy to handle
Reasonable bank charges
Arrive time:2-3 work days
Easy to handle

Nattokinase Manufacturers And Laboratory Shows

Nattokinase factory

With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.

Nattokinase manufacturer GMP Production Line

Plant extract testing laboratory

Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.

Our Mission And Philosophy

Where to buy Nattokinase? Where to find good Nattokinase Manufacturers and Nattokinase suppliers? Where can i Looking for Nattokinase purchase? Where can i purchase Nattokinase price and where to get Nattokinase for sale? Is that the very question that lingers in your mind every time you do purchasing? Well, that should not be your headache any longer since we are committed to help you get rid of it completely. We can provide you with the safest and most effective Nattokinase. To ensure the quality of any products that you buy on your platform, we have signed an investment and cooperation agreement with Natural Medicine Public Technical Service Platform, the largest and most professional third-party testing agency in China. Any extract you buy will have to pass the test of our strategic partner before delivery.
To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.