1. Weight loss
Celastrol is a leptin sensitizer and a promising agent for the pharmacological treatment of obesity. Discovery of leptin two decades ago created hopes for treatment of obesity. However, development of leptin resistance has been a big obstacle, mitigating a leptin-centric treatment of obesity. Celastrol suppresses food intake, blocks reduction of energy expenditure, and leads to up to 45% weight loss in hyperleptinemic dietinduced obese (DIO) mice by increasing leptin sensitivity. It clears the big obstacle of leptin resistance and recreats hopes for leptin-centric treatment of obesity.
Celastrol exhibits anti-inflammatory properties. It inhibits macrophage activation, MHC I and II processing, TNF-alpha, IL1, IL2, and IL6, it may be developed to be a new anti rheumatoid arthritis(RA) drug. It may be useful to minimize inflammation in Alzheimer's disease (AD).
Celastrol is a powerful antioxidant, in an isolated rat liver assay of lipidperoxidation, celastrol had a 50% inhibitory cocentration of 7 μM, equivalent to about 15 times the antioxidant potency of a-tocopherol.
Benefits of thunder god vine extract
It should be noted that this plant has a very low therapeutic index (difference between the effective dose and the toxic dose) and that overdosing is both easy to do and critical; supplementation is usually avoided for this reason.
1. Rheumatoid arthritis
Taking thunder god vine extract seems to relieve joint pain and swelling and improve physical function in people with RA. It might help by relieving inflammation and by changing the way the immune system responds to the arthritis. Applying a liquid preparation (tincture) of thunder god vine to the skin over affected joints seems to decrease morning stiffness, and swelling.
Recommended dosage —— 180-360 mg of thunder god vine extract per day for up to 20 weeks; a tincture of thunder god vine applied over affected joints five to six times daily.
2. Male contraception
Taking thunder god vine extract might be effective as a male contraceptive. The chemical constituents in the extract appear to act primarily on sperm development (eg, sperm head-tail separation), with sperm returning to normal after 6 weeks; however, high quality clinical trials are lacking to confirm efficacy or safety.
Recommended dosage —— 20 to 30 mg of extract per day
3. Kidney problems (Nephrotic syndrome, Kidney transplant)
Some clinical trials have demonstrated positive effects of extracts in renal-associated conditions, such as renal transplant and nephrotic syndrome. Taking thunder god vine before a kidney transplant and for 5 years thereafter might prevent transplant rejection and improve survival in some people undergoing kidney transplantation. Early research suggests thunder god vine may be effective for nephrotic syndrome in children. The effects may be largely due to immune-modulation rather than direct activity on the kidney.
Recommended dosage —— For kidney problems (nephrotic syndrome) in children: 1 mg per kg of body weight daily for up to 20 weeks.
*The Content here is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician with any questions you may have regarding a medical condition.