Arbutin

$120.00/KG
Specification:
Test by: HPLC
Quantity:
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Arbutin Introduction

Arbutin is commercially used as a skin-whitening agent in cosmetic industry. It works by competitive inhibition of the enzyme, tyrosinase, a key enzyme in the synthesis of melanin.

Depending on the spatial structure of the glycosidic linkage between glucose and hydroquinone, arbutin forms two epimers: α-arbutin and β-arbutin.

Product name

CAS Number

Molecular formula

Molecular structure

Beta-Arbutin

497-76-7

C12H16O7

Alpha-Arbutin

84380-01-8

C12H16O7

 

 

 

Botanical Source Of Beta-Arbutin: bearberry

Beta-Arbutin

 

Beta-Arbutin is often referred to as just Arbutin. It is can be naturally extracted from plants such as bearberry and synthesized by chemical method. Beta-Arbutin is currently one of the most widely used hypopigmenting agents in cosmetics, while plant-derived drugs containing Beta-Arbutin were initially used for the treatment of urinary tract infections, cystitis, kidney stones, and as diuretics in the medical field.

 

Alpha-Arbutin

 

Alpha-Arbutin is enzymatically synthesized from hydroquinone and saccharides through transglycosylation reaction. Various carbohydrate-active enzymes such as α-amylase, α-glucosidase, transglucosidase, sucrose phosphorylase, and dextransucrase have been employed to synthesize Alpha-Arbutin. It is one of the most advanced skin lightening ingredients on the market.

Arbutin Specification(COA)

ANALYSIS

SPECIFICATION

RESULTS

Assay

≥99.5%

99.8%  HPLC

Appearance

White fine powder

Complies

Arsenic

<2ppm

Complies

Melting Point

199~201±0.5℃

200.3~200.8℃

PH(1% water solution)

5.0-7.0

6.71

Transparency in water

Transparent colorless no suspended

Complies

Specific Optical Rotation

-66±2°

-65.6

Loss on drying

≤0.5

0.28%

Residue on ignition

≤0.5

0.15%

Infrared characteristic peak

1515cm-11220cm-11050cm-1±(5~8)cm-1

Complies

Hydrochinone

≤10ppm

Complies

Heavy metals

≤10ppm

Complies

Total Plate Count

≤300cfu/g

Complies

Total Yeast Count

≤100cfu/g

Complies

 

ANALYSIS

SPECIFICATION

RESULTS

Assay

≥99.5%

99.9%   HPLC

Appearance

White crystals or crystalline powder, IR spectrum conforms

Complies

Loss on drying

≤0.5

0.07

Residue on Ignition

≤0.5

0.05

Specific Optical Rotation

[a]D20= + 175.0°- +185.0°

+179.2°

Transparency in water

Transparent colorless no suspended

Complies

PH(1% water solution)

5.0-7.0

6.16

Melting Point

202.0℃~210.0℃

206.8℃

Hydroquinone

Negative

Negative

Lead(mg/kg)

≤10

<10

Arsenic(mg/kg)

≤2

<2

Mercury(mg/kg)

≤1

<1

Methanol(mg/kg)

≤2000

<1000

Plumbum

<2ppm

Complies

Microbiological Tests

 

 

Aerobic bacterial Count

≤1000cfu/g

Complies

Total Yeast & Mold

≤100cfu/g

Complies

Fecal Coliforms

Negative

Negative

Pseudomonas Aeruginosa

Negative

Negative

Staphylococcus

Negative

Negative

 

HPLC Chromatogram Of Arbutin

Arbutin HPLC

Arbutin Benefit and Usage

1. Skin whitening

Arbutin exhibits potent melanin-inhibiting properties and confers whitening effects on the skin. Sun damage and injury or inflammation to the skin from acne, eczema or psoriasis are the two main factors that cause melanin production on the skin. Arbutin can reduce the accumulation of pigment by inhibiting the production of melanin, which accumulates on the skin when tyrosine is oxidized. An enzyme called tyrosinase is the catalytic for this reaction. Scientists found arbutin has shown inhibitory actions against tyrosinase. When topically apply skincare products containing Arbutin, the inhabitation of tyrosinase results in the decrease of melanin, thus, a whiter complexion.

Recommended usage —— 2-7% (Beta-Arbutin); 0.2-5% (Alpha-Arbutin)

*The Content here is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician with any questions you may have regarding a medical condition.

Arbutin application

Arbutin is used as a skin whitening agent, a sunscreen agent and an antioxidant in cosmetic formulations. Arbutin soap, cream, serum and lotion are among the major lightening products you will found in the market.

Arbutin’s advantage over traditional skin-whitening products:

Arbutin can inhibit melanogenesis without causing melanocyte toxicity, unlike traditional depigmenting agents such as hydroquinone, corticosteroids, and kojic acid.

note

  1. Arbutin breaks down easily in acidic conditions, so the pH value of cosmetics containing Arbutin should be greater than 6.0.
  2. Please dissolve arbutin in 50℃ hot water before adding it to skin whitening products. (Arbutin is soluble in hot water, methanol or alcohol. Arbutin is partially soluble in cold water. Arbutin is insoluble in aether, chloroform or benzene.)
  3. Antioxidants should be added to cosmetics containing Arbutin.

Storage

Please tightly sealed Arbutin in containers. Store it in a cool dry place and away from sunlight and oxidizing agents.

learn more

Melanins are irregular polymeric structures derived from the amino acid tyrosine, and tyrosinase is known to be one of the key enzymes in mammalian melanin synthesis.

Tyrosinase is a copper-containing enzyme that catalyzes the rate-limiting step of melanin synthesis, which is oxidation of the aromatic amino acid tyrosine to DOPA and subsequently to DOPA-quinone. DOPA-quinone is then converted by multi-step reactions to melanin. As a result, tyrosinase is responsible for the formation of pigments such as melanins and other polyphenolic compounds from tyrosine by oxidation reactions.

  • Miracle Skin Whiting Effective "Alpha-Arbutin" Extracted From Natural Bearberry
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    Arbutin Manufacturers And Laboratory Shows

    Arbutin factory

    With an investment of 80 million RMB, the construction of the factory started from 2012 and was finished at 2014. There are three production lines that meet the GMP standard in our factory which can process 6,000 ton raw materials each year with production of 900 ton plant extract. Our factory has been issued with the GMP certificate by China Food and Drug Administration in the year 2014.

    Arbutin manufacturer GMP Production Line

    Plant extract testing laboratory

    Due to the complexity of plant extract and the deficiency industrial standards, one of our founders established a professional testing lab with an investment of 15 million RMB in 2014. The laboratory is equipped with five High performance liquid chromatography, one Gas Chromatograph, one Atomic Absorption Spectrometer, one Liquid mass spectrometry, one TLC scanner, one Automatic polarimeter, one Infrared Spectrometer, one Automatic melting point apparatus, one Mold incubator, one UV-visible spectrophotometer, one Portable Pressure Steam Sterilizer, one Single clean bench, one Explorer quasi-microbalance, one Electronic balance, and one Experimental resistance furnace.

    Our Mission And Philosophy

    Where to buy Arbutin? Where to find good Arbutin Manufacturers and Arbutin suppliers? Where can i Looking for Arbutin purchase? Where can i purchase Arbutin price and where to get Arbutin for sale? Is that the very question that lingers in your mind every time you do purchasing? Well, that should not be your headache any longer since we are committed to help you get rid of it completely. We can provide you with the safest and most effective Arbutin. To ensure the quality of any products that you buy on your platform, we have signed an investment and cooperation agreement with Natural Medicine Public Technical Service Platform, the largest and most professional third-party testing agency in China. Any extract you buy will have to pass the test of our strategic partner before delivery.
    To ensure that the production process is under our control, we have built factory of our own, what’s more, we have bought the most shares of several high-quality manufacturers. From raw material selection, to every specific production procedure, to the storage of every kind of product, every detail is under the inspection of our specialists with at least ten years’ experience.